Common infectious agents in multiple sclerosis: a case-control study in children.
Identifieur interne : 000439 ( Main/Exploration ); précédent : 000438; suivant : 000440Common infectious agents in multiple sclerosis: a case-control study in children.
Auteurs : Bernd Krone [Allemagne] ; Daniela Pohl ; Kevin Rostasy ; Elke Kahler ; Edgar Brunner ; Frank Oeffner ; John M. Grange ; Jutta G Rtner ; Folker HanefeldSource :
- Multiple sclerosis (Houndmills, Basingstoke, England) [ 1352-4585 ] ; 2008.
Descripteurs français
- KwdFr :
- Adolescent, Allemagne (épidémiologie), Anticorps antiviraux (sang), Enfant, Enfant d'âge préscolaire, Facteurs de risque, Femelle, Humains, Immunoglobuline G (sang), Immunoglobuline M (sang), Maladies virales (immunologie), Maladies virales (épidémiologie), Mâle, Sclérose en plaques (immunologie), Sclérose en plaques (épidémiologie), Études cas-témoins, Études séroépidémiologiques.
- MESH :
- immunologie : Maladies virales, Sclérose en plaques.
- sang : Anticorps antiviraux, Immunoglobuline G, Immunoglobuline M.
- épidémiologie : Allemagne, Maladies virales, Sclérose en plaques.
- Adolescent, Enfant, Enfant d'âge préscolaire, Facteurs de risque, Femelle, Humains, Mâle, Études cas-témoins, Études séroépidémiologiques.
- Wicri :
- geographic : Allemagne.
English descriptors
- KwdEn :
- Adolescent, Antibodies, Viral (blood), Case-Control Studies, Child, Child, Preschool, Female, Germany (epidemiology), Humans, Immunoglobulin G (blood), Immunoglobulin M (blood), Male, Multiple Sclerosis (epidemiology), Multiple Sclerosis (immunology), Risk Factors, Seroepidemiologic Studies, Virus Diseases (epidemiology), Virus Diseases (immunology).
- MESH :
- chemical , blood : Antibodies, Viral, Immunoglobulin G, Immunoglobulin M.
- geographic , epidemiology : Germany.
- epidemiology : Multiple Sclerosis, Virus Diseases.
- immunology : Multiple Sclerosis, Virus Diseases.
- Adolescent, Case-Control Studies, Child, Child, Preschool, Female, Humans, Male, Risk Factors, Seroepidemiologic Studies.
Abstract
Environmental factors, in particular infections, have been linked with the risk of developing multiple sclerosis (MS). The association of Epstein-Barr virus infection with childhood onset of MS has been recently recognized. As other infections characteristically experienced during childhood have not yet been studied in larger cohorts of paediatric MS, we conducted a study on 152 German children with MS (age at onset <16 years) and matched controls in the hope of gaining evidence for their possible aetiological role in MS. Patterns of antibody responses were determined to a range of infections which, in prior studies principally on adult patients, had revealed possible associations with MS. In this study on children the serology of several infections showed associations with MS. In the exceptional case of Chlamydia pneumoniae there was a significantly higher prevalence of IgM antibody but, more typically, as in the case of influenza A, measles, parainfluenza 2, varicella/zoster viruses and particularly to the herpes simplex virus type 2 (HSV-2) lysate antigen, there were significantly higher concentrations of IgG antibody. Additional investigations, however, make it highly unlikely that a relevant number of children have experienced infections with HSV-2. In general this study supports and emphasizes a complex infectious and immunologic background of MS.
DOI: 10.1177/1352458507082069
PubMed: 17942525
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
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Grange</name></author><author><name sortKey="G Rtner, Jutta" sort="G Rtner, Jutta" uniqKey="G Rtner J" first="Jutta" last="G Rtner">Jutta G Rtner</name></author><author><name sortKey="Hanefeld, Folker" sort="Hanefeld, Folker" uniqKey="Hanefeld F" first="Folker" last="Hanefeld">Folker Hanefeld</name></author></analytic><series><title level="j">Multiple sclerosis (Houndmills, Basingstoke, England)</title><idno type="ISSN">1352-4585</idno><imprint><date when="2008" type="published">2008</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent</term><term>Antibodies, Viral (blood)</term><term>Case-Control Studies</term><term>Child</term><term>Child, Preschool</term><term>Female</term><term>Germany (epidemiology)</term><term>Humans</term><term>Immunoglobulin G (blood)</term><term>Immunoglobulin M (blood)</term><term>Male</term><term>Multiple Sclerosis (epidemiology)</term><term>Multiple Sclerosis (immunology)</term><term>Risk Factors</term><term>Seroepidemiologic Studies</term><term>Virus Diseases (epidemiology)</term><term>Virus Diseases (immunology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adolescent</term><term>Allemagne (épidémiologie)</term><term>Anticorps antiviraux (sang)</term><term>Enfant</term><term>Enfant d'âge préscolaire</term><term>Facteurs de risque</term><term>Femelle</term><term>Humains</term><term>Immunoglobuline G (sang)</term><term>Immunoglobuline M (sang)</term><term>Maladies virales (immunologie)</term><term>Maladies virales (épidémiologie)</term><term>Mâle</term><term>Sclérose en plaques (immunologie)</term><term>Sclérose en plaques (épidémiologie)</term><term>Études cas-témoins</term><term>Études séroépidémiologiques</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Antibodies, Viral</term><term>Immunoglobulin G</term><term>Immunoglobulin M</term></keywords><keywords scheme="MESH" type="geographic" qualifier="epidemiology" xml:lang="en"><term>Germany</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Multiple Sclerosis</term><term>Virus Diseases</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Maladies virales</term><term>Sclérose en plaques</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Multiple Sclerosis</term><term>Virus Diseases</term></keywords><keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Anticorps antiviraux</term><term>Immunoglobuline G</term><term>Immunoglobuline M</term></keywords><keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Allemagne</term><term>Maladies virales</term><term>Sclérose en plaques</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adolescent</term><term>Case-Control Studies</term><term>Child</term><term>Child, Preschool</term><term>Female</term><term>Humans</term><term>Male</term><term>Risk Factors</term><term>Seroepidemiologic Studies</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adolescent</term><term>Enfant</term><term>Enfant d'âge préscolaire</term><term>Facteurs de risque</term><term>Femelle</term><term>Humains</term><term>Mâle</term><term>Études cas-témoins</term><term>Études séroépidémiologiques</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Allemagne</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Environmental factors, in particular infections, have been linked with the risk of developing multiple sclerosis (MS). The association of Epstein-Barr virus infection with childhood onset of MS has been recently recognized. As other infections characteristically experienced during childhood have not yet been studied in larger cohorts of paediatric MS, we conducted a study on 152 German children with MS (age at onset <16 years) and matched controls in the hope of gaining evidence for their possible aetiological role in MS. Patterns of antibody responses were determined to a range of infections which, in prior studies principally on adult patients, had revealed possible associations with MS. In this study on children the serology of several infections showed associations with MS. In the exceptional case of Chlamydia pneumoniae there was a significantly higher prevalence of IgM antibody but, more typically, as in the case of influenza A, measles, parainfluenza 2, varicella/zoster viruses and particularly to the herpes simplex virus type 2 (HSV-2) lysate antigen, there were significantly higher concentrations of IgG antibody. Additional investigations, however, make it highly unlikely that a relevant number of children have experienced infections with HSV-2. In general this study supports and emphasizes a complex infectious and immunologic background of MS.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">17942525</PMID><DateCompleted><Year>2008</Year><Month>04</Month><Day>17</Day></DateCompleted><DateRevised><Year>2007</Year><Month>12</Month><Day>19</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Print">1352-4585</ISSN><JournalIssue CitedMedium="Print"><Volume>14</Volume><Issue>1</Issue><PubDate><Year>2008</Year><Month>Jan</Month></PubDate></JournalIssue><Title>Multiple sclerosis (Houndmills, Basingstoke, England)</Title><ISOAbbreviation>Mult. Scler.</ISOAbbreviation></Journal><ArticleTitle>Common infectious agents in multiple sclerosis: a case-control study in children.</ArticleTitle><Pagination><MedlinePgn>136-9</MedlinePgn></Pagination><Abstract><AbstractText>Environmental factors, in particular infections, have been linked with the risk of developing multiple sclerosis (MS). The association of Epstein-Barr virus infection with childhood onset of MS has been recently recognized. As other infections characteristically experienced during childhood have not yet been studied in larger cohorts of paediatric MS, we conducted a study on 152 German children with MS (age at onset <16 years) and matched controls in the hope of gaining evidence for their possible aetiological role in MS. Patterns of antibody responses were determined to a range of infections which, in prior studies principally on adult patients, had revealed possible associations with MS. In this study on children the serology of several infections showed associations with MS. In the exceptional case of Chlamydia pneumoniae there was a significantly higher prevalence of IgM antibody but, more typically, as in the case of influenza A, measles, parainfluenza 2, varicella/zoster viruses and particularly to the herpes simplex virus type 2 (HSV-2) lysate antigen, there were significantly higher concentrations of IgG antibody. Additional investigations, however, make it highly unlikely that a relevant number of children have experienced infections with HSV-2. In general this study supports and emphasizes a complex infectious and immunologic background of MS.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Krone</LastName><ForeName>Bernd</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>Department of Virology, Georg August University Goettingen,Germany. bkrone@gwdg.de</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pohl</LastName><ForeName>Daniela</ForeName><Initials>D</Initials></Author><Author ValidYN="Y"><LastName>Rostasy</LastName><ForeName>Kevin</ForeName><Initials>K</Initials></Author><Author ValidYN="Y"><LastName>Kahler</LastName><ForeName>Elke</ForeName><Initials>E</Initials></Author><Author ValidYN="Y"><LastName>Brunner</LastName><ForeName>Edgar</ForeName><Initials>E</Initials></Author><Author ValidYN="Y"><LastName>Oeffner</LastName><ForeName>Frank</ForeName><Initials>F</Initials></Author><Author ValidYN="Y"><LastName>Grange</LastName><ForeName>John M</ForeName><Initials>JM</Initials></Author><Author ValidYN="Y"><LastName>Gärtner</LastName><ForeName>Jutta</ForeName><Initials>J</Initials></Author><Author ValidYN="Y"><LastName>Hanefeld</LastName><ForeName>Folker</ForeName><Initials>F</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2007</Year><Month>10</Month><Day>17</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Mult Scler</MedlineTA><NlmUniqueID>9509185</NlmUniqueID><ISSNLinking>1352-4585</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000914">Antibodies, Viral</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D007074">Immunoglobulin G</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D007075">Immunoglobulin M</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><CommentsCorrectionsList><CommentsCorrections RefType="CommentIn"><RefSource>Mult Scler. 2008 Jan;14(1):4-5</RefSource><PMID Version="1">18089671</PMID></CommentsCorrections></CommentsCorrectionsList><MeshHeadingList><MeshHeading><DescriptorName UI="D000293" MajorTopicYN="N">Adolescent</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000914" MajorTopicYN="N">Antibodies, Viral</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="N">blood</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D016022" MajorTopicYN="N">Case-Control Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D002648" MajorTopicYN="N">Child</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D002675" MajorTopicYN="N">Child, Preschool</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005858" MajorTopicYN="N" Type="Geographic">Germany</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007074" MajorTopicYN="N">Immunoglobulin G</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="N">blood</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D007075" MajorTopicYN="N">Immunoglobulin M</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="N">blood</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D009103" MajorTopicYN="N">Multiple Sclerosis</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="Y">epidemiology</QualifierName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012307" MajorTopicYN="N">Risk Factors</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016036" MajorTopicYN="N">Seroepidemiologic Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D014777" MajorTopicYN="N">Virus Diseases</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="Y">epidemiology</QualifierName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2007</Year><Month>10</Month><Day>19</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2008</Year><Month>4</Month><Day>18</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2007</Year><Month>10</Month><Day>19</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">17942525</ArticleId><ArticleId IdType="pii">1352458507082069</ArticleId><ArticleId IdType="doi">10.1177/1352458507082069</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Allemagne</li></country></list><tree><noCountry><name sortKey="Brunner, Edgar" sort="Brunner, Edgar" uniqKey="Brunner E" first="Edgar" last="Brunner">Edgar Brunner</name><name sortKey="G Rtner, Jutta" sort="G Rtner, Jutta" uniqKey="G Rtner J" first="Jutta" last="G Rtner">Jutta G Rtner</name><name sortKey="Grange, John M" sort="Grange, John M" uniqKey="Grange J" first="John M" last="Grange">John M. Grange</name><name sortKey="Hanefeld, Folker" sort="Hanefeld, Folker" uniqKey="Hanefeld F" first="Folker" last="Hanefeld">Folker Hanefeld</name><name sortKey="Kahler, Elke" sort="Kahler, Elke" uniqKey="Kahler E" first="Elke" last="Kahler">Elke Kahler</name><name sortKey="Oeffner, Frank" sort="Oeffner, Frank" uniqKey="Oeffner F" first="Frank" last="Oeffner">Frank Oeffner</name><name sortKey="Pohl, Daniela" sort="Pohl, Daniela" uniqKey="Pohl D" first="Daniela" last="Pohl">Daniela Pohl</name><name sortKey="Rostasy, Kevin" sort="Rostasy, Kevin" uniqKey="Rostasy K" first="Kevin" last="Rostasy">Kevin Rostasy</name></noCountry><country name="Allemagne"><noRegion><name sortKey="Krone, Bernd" sort="Krone, Bernd" uniqKey="Krone B" first="Bernd" last="Krone">Bernd Krone</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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